Hydrochloric Acid → 2-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

HRID 728924Notes

Reaction equation

HRID 728924 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20](N)=[O:21])[CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:23].[K+].Cl.O>C(O)CO>[C:1]1([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20]([OH:21])=[O:23])[CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 109900971-Benzyl-4-phenyl-piperazine-2-carboxamide

Product 1

HCID 149988012-Piperazinecarboxylic acid,4-phenyl-1-(phenylmethyl)-

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

Suspend 4-phenyl-1-(phenylmethyl)-2-piperazinecarboxamide (14.5 g, 49 mmol)in ethylene glycol (400 mL) and add potassium hydroxide (27.5 g, 490 mmol).Heat this mixture to 150° C. for 18 h. After this time, remove the solvent in vacuo. Add 6M hydrochloric acid (81.5 mL, 0.49 mol) and water (300 mL) and filter the resultant solid to obtain the title compound.

Workup

  1. customAfter this time, remove the solvent in vacuo
  2. filtrationfilter the resultant solid

Sources & evidence

ORD record
ord-d1cdf371fdc84ebdaeb2c748844826df
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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