2,3-Dibromopropionamide → 4-[3-(Acetylamino)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide

HRID 728929Notes

Reaction equation

HRID 728929 reaction equation
[C:1]1([CH2:7][NH:8][CH2:9][CH2:10][NH:11][C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:21])[CH3:20])[CH:15]=[CH:16][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:23]([CH2:27]Br)[C:24]([NH2:26])=[O:25]>>[C:19]([NH:18][C:14]1[CH:13]=[C:12]([N:11]2[CH2:10][CH2:9][N:8]([CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:23]([C:24]([NH2:26])=[O:25])[CH2:27]2)[CH:17]=[CH:16][CH:15]=1)(=[O:21])[CH3:20]

Participants

3

Reactant 2

HCID 857982,3-DibromopropionamideHCID 14998757N-[3-[[2-[(phenylmethyl)amino]ethyl]amino]phenyl]acetamide

Product 1

HCID 149987584-[3-(Acetylamino)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide

Procedure

In a manner similar to Preparation 1, react N-[3-[[2-[(phenylmethyl)amino]ethyl]amino]phenyl]acetamide (25.6 g, 90.4 mmol) with 2,3-dibromopropanamide (41.8 g, 180.8 mmol) to obtain the titlecompound.

Workup

  1. customIn a manner similar to Preparation 1
  2. customto obtain the titlecompound

Sources & evidence

ORD record
ord-8bb2b618831245f59fdde9b22b1dd593
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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