HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(4-Chloromethylphenyl)-2-methyl-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [4-(2-Methylimidazol-1-yl)phenyl]methanol | HCID 11735617 | — |
| Product | 1-(4-Chloromethylphenyl)-2-methyl-1H-imidazole | HCID 14998821 | — |
Reaction Steps
To 4-(2-methyl-1H-imidazole-1-yl)benzenemethanol add thionyl chloride. Monitor the progress of the reaction by thin-layer chromatography. Upon completion remove the excess thionyl chloride in vacuo. Partition the residue between 1N NaOH and CH2Cl2. Separate and dry the organic layer. Remove the solvent in vacuo to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05051422 |
| Source dataset | uspto-grants-1991_09 |
| ORD ID | ord-245439cab45d4f77bb5fbb28c73a2f97 |
| Source note | uspto-grants-1991_09 |