4-(3-Aminophenyl)-2-piperazinemethanol → 1-(3-Aminophenyl)-3-[[[4-(2-methyl-1H-imidazol-1-yl)phenyl]methoxy]methyl]piperazine

HRID 728942Notes

Reaction equation

HRID 728942 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH:10]([CH2:14][OH:15])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH:28]=[CH:27][N:26]=[C:25]2[CH3:29])=[CH:20][CH:19]=1>>[NH2:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][NH:11][CH:10]([CH2:14][O:15][CH2:17][C:18]3[CH:19]=[CH:20][C:21]([N:24]4[CH:28]=[CH:27][N:26]=[C:25]4[CH3:29])=[CH:22][CH:23]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 149988204-(3-Aminophenyl)-2-piperazinemethanolHCID 149988211-(4-Chloromethylphenyl)-2-methyl-1H-imidazole

Product 1

HCID 149988221-(3-Aminophenyl)-3-[[[4-(2-methyl-1H-imidazol-1-yl)phenyl]methoxy]methyl]piperazine

Procedure

In a manner similar to Preparation 19, react 4-(3-aminophenyl)-2-piperazinemethanol with 1-[4-(chloromethyl)phenyl]-2-methyl-1H-imidazole to obtain the title compound.

Workup

  1. customIn a manner similar to Preparation 19

Sources & evidence

ORD record
ord-8644a1e1f5b04ee09a05d9439918af71
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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