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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 728967Generated: October 31, 2026

Acetaldehyde → 4-(4-Ethoxyphenyl)-N-(2-methoxyethyl)-N-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide

https://huagongshe.com/reaction/728967

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetaldehydeHCID 177—
ReactantGlyceraldehydeHCID 751—
ReactantAmmonium HydroxideHCID 14923—
ReactantN-(4-Aminophenyl)-4-(4-ethoxyphenyl)-N-(2-methoxyethyl)-1-(phenylmethyl)-2-piperazinecarboxamideHCID 14998839—
Product4-(4-Ethoxyphenyl)-N-(2-methoxyethyl)-N-[4-(2-methyl-1H-imidazol-1-yl)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamideHCID 14998778—

Reaction Steps

In a manner similar to Preparation 34, react N-(4-aminophenyl)-4-(4-ethoxyphenyl)-N-(2-methoxyethyl)-1-(phenylmethyl)-2-piperazinecarboxamide with glyceraldehyde, acetaldehyde and ammonium hydroxide to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05051422
Source datasetuspto-grants-1991_09
ORD IDord-8745d5e2b1044781a1e3a4275bdc9ebf
Source noteuspto-grants-1991_09