Formaldehyde → HCID 14998845, compound

HRID 728977Notes

Reaction equation

HRID 728977 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([CH:11]2[CH2:16][N:15]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[C:19]([Cl:24])[CH:18]=3)[CH2:14][CH2:13][N:12]2[CH2:25][CH3:26])=[O:10])=[CH:4][CH:3]=1.[OH-].[NH4+:28].[CH2:29]=O.[CH:31]([CH:33]=O)=O>>[Cl:24][C:19]1[CH:18]=[C:17]([N:15]2[CH2:14][CH2:13][N:12]([CH2:25][CH3:26])[CH:11]([C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([N:1]4[CH:33]=[CH:31][N:28]=[CH:29]4)=[CH:3][CH:4]=3)=[O:10])[CH2:16]2)[CH:22]=[CH:21][C:20]=1[Cl:23]

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 7860GlyoxalHCID 14923Ammonium HydroxideHCID 14998844HCID 14998844, compound

Product 1

HCID 14998845HCID 14998845, compound

Procedure

In a manner similar to preparation 34, react N-(4-aminophenyl)-4-(3,4-dichlorophenyl)-1-ethyl-2-piperazinecarboxamide, ammonium hydroxide, aqueous formaldehyde, and glyoxal to obtain the title compound.

Workup

  1. customIn a manner similar to preparation 34

Sources & evidence

ORD record
ord-dd2d84a489854d6cb921b8467d26b7b5
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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