HCID 67902768, compound → HCID 19755031, compound

HRID 728979Notes

Reaction equation

HRID 728979 reaction equation
[ClH:1].Cl.Cl.[N:4]1([C:9]2[CH:37]=[CH:36][C:12]([C:13]([NH:15][CH2:16][CH:17]3[CH2:22][N:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:19][N:18]3CC3C=CC=CC=3)=[O:14])=[CH:11][CH:10]=2)[CH:8]=[CH:7][N:6]=[CH:5]1>[OH-].[OH-].[Pd+2]>[ClH:1].[ClH:1].[ClH:1].[N:4]1([C:9]2[CH:10]=[CH:11][C:12]([C:13]([NH:15][CH2:16][CH:17]3[CH2:22][N:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH2:20][CH2:19][NH:18]3)=[O:14])=[CH:36][CH:37]=2)[CH:8]=[CH:7][N:6]=[CH:5]1

Participants

3

Reactant 1

HCID 67902768HCID 67902768, compound

Product 1

HCID 19755031HCID 19755031, compound

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

In a manner similar to Example 1, react 4-(1H-imidazol-1-yl)-N-[[4-phenyl-1-(phenylmethyl)piperazin-2-yl]methyl]benzamide trihydrochloride (12.3 g, 22 mmol) with H2 over Pd(OH)2 (1.5 g) catalyst to give the title compound.

Sources & evidence

ORD record
ord-744ede4af576427282f22a8a92d6fd8e
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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