4-[(Methylsulfonyl)amino]-N-[[4-(3-methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]benzamide dihydrochloride → N-[[4-(3-Methoxyphenyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide dihydrochloride

HRID 728980Notes

Reaction equation

HRID 728980 reaction equation
[ClH:1].Cl.[CH3:3][S:4]([NH:7][C:8]1[CH:38]=[CH:37][C:11]([C:12]([NH:14][CH2:15][CH:16]2[CH2:21][N:20]([C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=3)[CH2:19][CH2:18][N:17]2CC2C=CC=CC=2)=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]>[OH-].[OH-].[Pd+2]>[ClH:1].[ClH:1].[CH3:29][O:28][C:24]1[CH:23]=[C:22]([N:20]2[CH2:19][CH2:18][NH:17][CH:16]([CH2:15][NH:14][C:12](=[O:13])[C:11]3[CH:37]=[CH:38][C:8]([NH:7][S:4]([CH3:3])(=[O:6])=[O:5])=[CH:9][CH:10]=3)[CH2:21]2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 1

HCID 197550214-[(Methylsulfonyl)amino]-N-[[4-(3-methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]benzamide dihydrochloride

Product 1

HCID 19755012N-[[4-(3-Methoxyphenyl)piperazin-2-yl]methyl]-4-[(methylsulfonyl)amino]benzamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 9942167Palladium hydroxideCatalyst

Procedure

In a manner similar to Example 1, react 4-[(methylsulfonyl)amino]-N-[[4-(3-methoxyphenyl)-1-(phenylmethyl)piperazin-2-yl]methyl]benzamide dihydrochloride (2.3 g, 4 mmol) with H2 over Pd(OH)2 (0.3 g) catalyst to give the title compound.

Sources & evidence

ORD record
ord-c8d7b31e75a043ad809dcd6aa3779336
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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