4-(1-Imidazolyl)benzoic Acid → HCID 14998864, compound

HRID 728985Notes

Reaction equation

HRID 728985 reaction equation
[N:1]1([C:6]2[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[Cl:15][C:16]1[CH:17]=[C:18]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([CH3:32])([CH3:31])[CH3:30])[CH2:25][CH:24]2[CH2:33][NH2:34])[CH:19]=[CH:20][C:21]=1[Cl:22]>>[Cl:15][C:16]1[CH:17]=[C:18]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:25][CH:24]2[CH2:33][NH:34][C:10](=[O:12])[C:9]2[CH:8]=[CH:7][C:6]([N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)=[CH:14][CH:13]=2)[CH:19]=[CH:20][C:21]=1[Cl:22]

Participants

3

Reactant 2

HCID 7365294-(1-Imidazolyl)benzoic AcidHCID 14998782HCID 14998782, compound

Product 1

HCID 14998864HCID 14998864, compound

Procedure

In a manner similar to preparation 7, react 4-(1H-imidazol-1-yl)benzoic acid, 1,1-carbonyldiimidazole and 1-(3,4-dichlorophenyl)-4-(1,1-dimethylethyl)-2-piperazinemethanamine to obtain the title compound.

Workup

  1. customIn a manner similar to preparation 7

Sources & evidence

ORD record
ord-147ccbd2551343968f699dc2600d9a82
Source dataset
uspto-grants-1991_09
Patent number
US05051422

Reaction notes

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