Sodium Iodide → 5-[5-(2,6-Dichloro-4-cyanophenoxy)pentyl]-3-methylisoxazole

HRID 728997ノート

反応式

HRID 728997 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([Cl:11])[C:9]=1[OH:10])[C:5]#[N:6].Br[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[O:22][N:21]=[C:20]([CH3:23])[CH:19]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CN(C)C=O.COC(C)(C)C.CCCCCC>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]#[N:6])[CH:7]=[C:8]([Cl:11])[C:9]=1[O:10][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]1[O:22][N:21]=[C:20]([CH3:23])[CH:19]=1

参加物

7

反応物 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 74685ChloroxynilHCID 135440465-(5-Bromopentyl)-3-methylisoxazole

生成物 1

HCID 104723405-[5-(2,6-Dichloro-4-cyanophenoxy)pentyl]-3-methylisoxazole

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 21982663Methyl t-butylether hexane溶媒

実験手順

5-[5-(2,6-Dichloro-4-cyanophenoxy)pentyl]-3-methylisoxazole [IX; Y=(CH2)5, Z=N, R=CH3, R1 =2-Cl, R2 =6-Cl] was prepared from 13.4 g 3,5-dichloro-4-hydroxybenzonitrile, 23.2 g 5-(5-bromopentyl)-3-methylisoxazole, 20.7 g potassium carbonate and 15 g sodium iodide in 250 ml dimethylformamide, similar to the procedure of Example 1, and was obtained in the form of colorless crystals (11.6 g), m.p. 59°-60° C. (from tertiary-butyl methyl ether-hexane).

出典と根拠

ORDレコード
ord-0bc84a7250e54f7893f5799bf4c32745
出典データセット
uspto-grants-1991_09
特許番号
US05051437

反応ノート

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