反应详情

A solution of 7.2 g 4-hydroxybenzaldehyde, 14.6 g 5-(5-bromopentyl)-3-methylisoxazole, 4 g potassium hydroxide in 100 ml acetonitrile was heated at reflux for 1.5 hours. The reaction mixture was cooled and filtered, the solvent removed, and the residue recrystallized from isopropyl acetate-hexane to give 10.8 g 4-[5(3-methyl-5-isoxazolyl)pentyloxy]benzaldehyde as a pale-yellow powder.

1. temperatureat reflux for 1.5 hours
2. temperatureThe reaction mixture was cooled
3. filtrationfiltered
4. customthe solvent removed
5. customthe residue recrystallized from isopropyl acetate-hexane