Sodium Hydroxide → HCID 14800668, compound

HRID 729020Notes

Reaction equation

HRID 729020 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:29]=[CH:28][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([O:23]C)=[O:22])=[CH:15][CH:14]=1.[OH-].[Na+]>C(O)C>[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][O:12][C:13]1[CH:29]=[CH:28][C:16]([CH2:17][C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][CH:27]=2)[C:21]([OH:23])=[O:22])=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14800667HCID 14800667, compound

Product 1

HCID 14800668HCID 14800668, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 3-(4-(2-quinolinylmethyloxy)benzyl)benzoate (0.05 mol) is heated at reflux in a 9:1 mixture of ethanol and 0.5 N aqueous NaOH (450 ml). After several hours the clear reaction is evaporated. The solid residue is takenup in water and acidified. The resulting crystalline product is isolated byfiltration and dried by suction with a rubber dam to obtain 3-(4-(2-quinolinylmethyloxy)benzyl)benzoic acid.

Workup

  1. customAfter several hours the clear reaction
  2. customis evaporated
  3. customThe resulting crystalline product is isolated byfiltration
  4. customdried by suction with a rubber dam

Sources & evidence

ORD record
ord-6fed60ed214f4406b4b879f7b36764a7
Source dataset
uspto-grants-1991_09
Patent number
US05051427

Reaction notes

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