反应详情

5.34 g (30 millimoles) of methyl 2-methylphenylglyoxylate and 5.34 g (30 millimoles) of N-bromosuccinimide in 1,000 ml of tetrachloromethane are exposed to a 300 W Hg vapor lamp for one hour. Thereafter, the organic phase is washed once with water and three times with sodium bicarbonate solution and dried over sodium sulfate/sodium carbonate. It is evaporated down and the crude product is then chromatographed over silica gel using 9:1 methyl tert-butyl ether/n-hexane. 3.8 g (49%) of the abovementioned compound is obtained as a yellow oil.

1. washThereafter, the organic phase is washed once with water and three times with sodium bicarbonate solution
2. dry with materialdried over sodium sulfate/sodium carbonate
3. customIt is evaporated down
4. customthe crude product is then chromatographed over silica gel using 9:1 methyl tert-butyl ether/n-hexane