N-bromobutanimide → Methyl 2-[2-(bromomethyl)phenyl]-2-oxoacetate

関与物質

反応手順

5.34 g (30 millimoles) of methyl 2-methylphenylglyoxylate and 5.34 g (30 millimoles) of N-bromosuccinimide in 1,000 ml of tetrachloromethane are exposed to a 300 W Hg vapor lamp for one hour. Thereafter, the organic phase is washed once with water and three times with sodium bicarbonate solution and dried over sodium sulfate/sodium carbonate. It is evaporated down and the crude product is then chromatographed over silica gel using 9:1 methyl tert-butyl ether/n-hexane. 3.8 g (49%) of the abovementioned compound is obtained as a yellow oil.

情報源と証拠