反应详情

A mixture of 2-methyl-3-(2-chloroethyl)-4-chloro-8-methoxyquinoline hydrochloride (15.33 g, 50 mmol), 4-methoxy-2-methylaniline (9.0 ml. 70 mmol) and 2-propanol (200 ml) was heated at reflux for 2 days, then evaporated. The crude product was triturated with ether then recrystallised twice from aqueous ethanol to give the title compound (3.16g), m.p. 163°-167°.

1. temperaturewas heated
2. temperatureat reflux for 2 days
3. customevaporated
4. customThe crude product was triturated with ether
5. customthen recrystallised twice from aqueous ethanol