Hydrochloric Acid → Hydrochloric Acid

HRID 729128Notes

Reaction equation

HRID 729128 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:7])[OH:6].[H][H].[ClH:16]>O>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)(=[O:6])[OH:7].[ClH:16]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 101042063-Aminopropyl(phenyl)phosphinic acidHCID 178418361HCID 178418361, compound2×

Product 2

HCID 313Hydrochloric AcidHCID 99207013-Aminopropyl(cyclohexyl)phosphinic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.5 g of 3-aminopropyl(phenyl)phosphinic acid in 10 ml of water and 7.9 ml of 1N hydrochloric acid is treated with hydrogen at 25° in the presence of 0.2 g of Nishimura-catalyst (Rh/PtO2). After 1.2 hours hydrogen up-take stops. The reaction mixture is filtered and the filtrate evaporated to dryness. The residue is recrystallized frommethanol/propylenoxide to give 1.2 g of 3-aminopropyl(cyclohexyl)phosphinicacid ×0,4 mol hydrochloric acid as a white solid, m.p. 202°-203°.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate evaporated to dryness
  3. customThe residue is recrystallized frommethanol/propylenoxide

Sources & evidence

ORD record
ord-5640e9fdf8764336a631b1efbf86ea7c
Source dataset
uspto-grants-1991_09
Patent number
US05051524

Reaction notes

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