4-(Difluoromethoxy)aniline → 2-[4-(Difluoromethoxy)benzyl]-4-{[4-(difluoromethoxy)phenyl]amino}-5-phenylisothiazol-3(2H)-one 1,1-dioxide

HRID 729282Notes

Reaction equation

HRID 729282 reaction equation
Cl[C:2]1[C:3](=[O:26])[N:4]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][CH:23]([F:25])[F:24])=[CH:18][CH:17]=2)[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:27][CH:28]([F:37])[O:29][C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=1>CC#N>[F:24][CH:23]([F:25])[O:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][N:4]2[C:3](=[O:26])[C:2]([NH:34][C:33]3[CH:35]=[CH:36][C:30]([O:29][CH:28]([F:27])[F:37])=[CH:31][CH:32]=3)=[C:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[S:5]2(=[O:14])=[O:13])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 7373634-(Difluoromethoxy)anilineHCID 686617234-Chloro-2-[4-(difluoromethoxy)benzyl]-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 117133692-[4-(Difluoromethoxy)benzyl]-4-{[4-(difluoromethoxy)phenyl]amino}-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

4-Chloro-2-[4-(difluoromethoxy)benzyl]-5-phenylisothiazol-3(2H)-one 1,1-dioxide (80 mg, 0.2 mmol) and 4-(difluoromethoxy)-aniline (64 mg, 0.4 mmol) were mixed in MeCN (2 mL).

Sources & evidence

ORD record
ord-99c505b2c9ec41dbbc882f9bf6a9d9f5
Source dataset
uspto-grants-2009_09
Patent number
US07582629B2

Reaction notes

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