HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Difluoromethoxy)aniline → 2-[4-(Difluoromethoxy)benzyl]-4-{[4-(difluoromethoxy)phenyl]amino}-5-phenylisothiazol-3(2H)-one 1,1-dioxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Difluoromethoxy)aniline | HCID 737363 | — |
| Reactant | 4-Chloro-2-[4-(difluoromethoxy)benzyl]-5-phenylisothiazol-3(2H)-one 1,1-dioxide | HCID 68661723 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-[4-(Difluoromethoxy)benzyl]-4-{[4-(difluoromethoxy)phenyl]amino}-5-phenylisothiazol-3(2H)-one 1,1-dioxide | HCID 11713369 | — |
Reaction Steps
4-Chloro-2-[4-(difluoromethoxy)benzyl]-5-phenylisothiazol-3(2H)-one 1,1-dioxide (80 mg, 0.2 mmol) and 4-(difluoromethoxy)-aniline (64 mg, 0.4 mmol) were mixed in MeCN (2 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582629B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-99c505b2c9ec41dbbc882f9bf6a9d9f5 |
| Source note | uspto-grants-2009_09 |