4-Aminophenol → HCID 11696449, compound

HRID 729319Notes

Reaction equation

HRID 729319 reaction equation
Cl[C:2]1[C:3](=[O:19])[N:4]([CH2:15][CH2:16][O:17][CH3:18])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][CH:22]=1>>[OH:27][C:24]1[CH:25]=[CH:26][C:21]([NH:20][C:2]2[C:3](=[O:19])[N:4]([CH2:15][CH2:16][O:17][CH3:18])[S:5](=[O:14])(=[O:13])[C:6]=2[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 4034-AminophenolHCID 672439094-Chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 11696449HCID 11696449, compound

Procedure

The title compound was prepared from 4-chloro-2-(2-methoxyethyl)-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 4-aminophenol in a similar manner as described for Examples 9 and 13. 1H NMR (400 MHz, CD3CN): δ 3.37 (s, 3H), 3.72 (t, 2H), 3.90 (t, 2H), 6.40-6.45 (m, 2H), 6.65-6.71 (m, 2H), 6.82 (bs, 1H), 7.10-7.20 (m, 4H), 7.23-7.29 (m, 1H), 7.63 (bs, 1H); Mass Spectrum: M−H+ 373.

Sources & evidence

ORD record
ord-d636dc427a234f38bc171646024de483
Source dataset
uspto-grants-2009_09
Patent number
US07582629B2

Reaction notes

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