6-(Morpholino)pyridin-3-amine → HCID 11495021, compound

HRID 729322Notes

Reaction equation

HRID 729322 reaction equation
Cl[C:2]1[C:3](=[O:16])[N:4]([CH3:15])[S:5](=[O:14])(=[O:13])[C:6]=1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[N:17]1([C:23]2[N:28]=[CH:27][C:26]([NH2:29])=[CH:25][CH:24]=2)[CH2:22][CH2:21][O:20][CH2:19][CH2:18]1>>[CH3:15][N:4]1[C:3](=[O:16])[C:2]([NH:29][C:26]2[CH:27]=[N:28][C:23]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[CH:24][CH:25]=2)=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[S:5]1(=[O:14])=[O:13]

Participants

3

Reactant 2

HCID 1040596-(Morpholino)pyridin-3-amineHCID 686620174-Chloro-2-methyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide

Product 1

HCID 11495021HCID 11495021, compound

Procedure

The title compound was prepared from 4-chloro-2-methyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 6-morpholin-4-ylpyridin-3-amine in a similar manner as described for Examples 9 and 13. 1H NMR (400 MHz, CD3CN): δ 3.20 (s, 3H), 3.26-3.30 (m, 4H), 3.65-3.70 (m, 4H), 6.31 (d, 1H), 6.94-6.99 (m, 1H), 7.11-7.22 (m, 4H), 7.25-7.30 (m, 1H), 7.58 (bs, 1H), 7.71 (d, 1H); Mass Spectrum: M−H+ 399.

Sources & evidence

ORD record
ord-35fe45b8e6be4f689639c8dcac8b709c
Source dataset
uspto-grants-2009_09
Patent number
US07582629B2

Reaction notes

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