Sodium Hydroxide → (5-{2-[4-(5-Bromo-2-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid

HRID 729470Notes

Reaction equation

HRID 729470 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:32])=[C:6]([CH:31]=1)[O:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]3[N:21]=[N:22][N:23]([CH2:25][C:26]([O:28]CC)=[O:27])[N:24]=3)=[CH:16][N:15]=2)[CH2:10][CH2:9]1.[OH-].[Na+]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([F:32])=[C:6]([CH:31]=1)[O:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:15]=[CH:16][C:17]([C:20]3[N:21]=[N:22][N:23]([CH2:25][C:26]([OH:28])=[O:27])[N:24]=3)=[CH:18][N:19]=2)[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 86621805Ethyl (5-{2-[4-(5-bromo-2-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetate

Product 1

HCID 57832727(5-{2-[4-(5-Bromo-2-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetic acid

Procedure

The title compound was prepared in a similar manner as that described for Example 3 (step 5) from ethyl (5-{2-[4-(5-bromo-2-fluorophenoxy)piperidin-1-yl]pyrimidin-5-yl}-2H-tetrazol-2-yl)acetate and aqueous NaOH.

Sources & evidence

ORD record
ord-f99d5fe714fe43d599c49f0f5634cb2c
Source dataset
uspto-grants-2009_09
Patent number
US07582633B2

Reaction notes

Loading…