HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Azetidine, 3-(2-bromo-5-fluorophenoxy)-, hydrochloride (1:1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 58367545 | HCID 58367545 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Azetidine, 3-(2-bromo-5-fluorophenoxy)-, hydrochloride (1:1) | HCID 67300218 | — |
Reaction Steps
To tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate (2.28 g, 6.59 mmol) in dioxane (40 mL) was added 4 M HCl in dioxane (4.49 mL, 19.8 mmol). After a period of 18 h, the white solid was filtered and washed with cold dioxane to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582633B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-0c30d5f758f748ccaa44cd06639e40c0 |
| Source note | uspto-grants-2009_09 |