Hydrochloric Acid → Azetidine, 3-(2-bromo-5-fluorophenoxy)-, hydrochloride (1:1)

HRID 729480Notes

Reaction equation

HRID 729480 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:3]=1[O:4][CH:5]1[CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6]1.[ClH:21]>O1CCOCC1>[ClH:21].[Br:1][C:2]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:3]=1[O:4][CH:5]1[CH2:8][NH:7][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58367545HCID 58367545, compound

Product 1

HCID 67300218Azetidine, 3-(2-bromo-5-fluorophenoxy)-, hydrochloride (1:1)

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To tert-butyl 3-(2-bromo-5-fluorophenoxy)azetidine-1-carboxylate (2.28 g, 6.59 mmol) in dioxane (40 mL) was added 4 M HCl in dioxane (4.49 mL, 19.8 mmol). After a period of 18 h, the white solid was filtered and washed with cold dioxane to give the title compound.

Workup

  1. filtrationthe white solid was filtered
  2. washwashed with cold dioxane

Sources & evidence

ORD record
ord-0c30d5f758f748ccaa44cd06639e40c0
Source dataset
uspto-grants-2009_09
Patent number
US07582633B2

Reaction notes

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