Ammonia → HCID 45380634, compound

HRID 729482Notes

Reaction equation

HRID 729482 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15](OC)=[O:16])=[N:13][CH:14]=2)[CH2:6]1.[NH3:24]>CO>[Br:1][C:2]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][C:3]=1[O:4][CH:5]1[CH2:8][N:7]([C:9]2[N:10]=[CH:11][C:12]([C:15]([NH2:24])=[O:16])=[N:13][CH:14]=2)[CH2:6]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 58367548HCID 58367548, compound

Product 1

HCID 45380634HCID 45380634, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To methyl 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxylate (0.080 g, 2.1 mmol) in MeOH was bubbled ammonia and the mixture was heated at 50° C. After 2 d, the methanol was evaporated followed by the addition of ether. The solid was filtered to provide the title compound as a white solid.

Workup

  1. customthe methanol was evaporated
  2. additionfollowed by the addition of ether
  3. filtrationThe solid was filtered

Sources & evidence

ORD record
ord-7cd9bd263dd8487d8d6f087e9594ac51
Source dataset
uspto-grants-2009_09
Patent number
US07582633B2

Reaction notes

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