Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 58367548 | HCID 58367548 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 45380634 | HCID 45380634 | — |
Reaction Steps
To methyl 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxylate (0.080 g, 2.1 mmol) in MeOH was bubbled ammonia and the mixture was heated at 50° C. After 2 d, the methanol was evaporated followed by the addition of ether. The solid was filtered to provide the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07582633B2 |
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| Source dataset | uspto-grants-2009_09 |
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| ORD ID | ord-7cd9bd263dd8487d8d6f087e9594ac51 |
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| Source note | uspto-grants-2009_09 |
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