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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 729482Generated: October 29, 2026

Ammonia → HCID 45380634, compound

https://huagongshe.com/reaction/729482

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
ReactantHCID 58367548HCID 58367548—
SolventMethanolHCID 887—
ProductHCID 45380634HCID 45380634—

Reaction Conditions

Temperature50 °C

Reaction Steps

To methyl 5-[3-(2-bromo-5-fluorophenoxy)azetidin-1-yl]pyrazine-2-carboxylate (0.080 g, 2.1 mmol) in MeOH was bubbled ammonia and the mixture was heated at 50° C. After 2 d, the methanol was evaporated followed by the addition of ether. The solid was filtered to provide the title compound as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07582633B2
Source datasetuspto-grants-2009_09
ORD IDord-7cd9bd263dd8487d8d6f087e9594ac51
Source noteuspto-grants-2009_09