Hydrochloric Acid → 1-(2-Fluorobenzoyl)piperazine hydrochloride

HRID 729616Notes

Reaction equation

HRID 729616 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:22])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23].O1CCOCC1>ClCCl>[ClH:23].[F:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:14]([N:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)=[O:22]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 4863006Tert-butyl 4-(2-fluorobenzoyl)piperazine-1-carboxylate

Product 1

HCID 545945301-(2-Fluorobenzoyl)piperazine hydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(2-fluoro-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester (16.3 g, 53 mmol) in dichloromethane (100 mL), add a solution of 4 M HCl in 1,4-dioxane (40 mL, 159 mmol) and stir the reaction mixture at room temperature overnight. Add Et2O to the resultant white suspension and evaporate solvents under reduced pressure to give 12.6 g of (2-fluoro-phenyl)-piperazin-1-yl-methanone hydrochloride. ES+ (m/z) 209[M+H]).

Workup

  1. customAdd Et2O to the resultant white suspension and evaporate solvents under reduced pressure

Sources & evidence

ORD record
ord-96b50b38acd144b794c73d6e711a5ad9
Source dataset
uspto-grants-2009_09
Patent number
US07582638B2

Reaction notes

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