Hydrochloric Acid → 1-[5-(1-Methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-[1-(piperidin-4-yloxy)-isoquinolin-4-yl]-urea dihydrochloride

HRID 729620Notes

Reaction equation

HRID 729620 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:25]([NH:32][C:33]([NH:35][C:36]3[N:37]([C:45]4[CH:50]=[CH:49][C:48]([CH3:51])=[CH:47][CH:46]=4)[N:38]=[C:39]([C:41]4([CH3:44])[CH2:43][CH2:42]4)[CH:40]=3)=[O:34])=[CH:24][N:23]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[ClH:1].[CH3:44][C:41]1([C:39]2[CH:40]=[C:36]([NH:35][C:33]([NH:32][C:25]3[C:26]4[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=4)[C:22]([O:21][CH:18]4[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]4)=[N:23][CH:24]=3)=[O:34])[N:37]([C:45]3[CH:50]=[CH:49][C:48]([CH3:51])=[CH:47][CH:46]=3)[N:38]=2)[CH2:43][CH2:42]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 690528384-(4-{3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-ureido}-isoquinolin-1-yloxy)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 690540351-[5-(1-Methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-3-[1-(piperidin-4-yloxy)-isoquinolin-4-yl]-urea dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add HCl 4 M in dioxane (2.4 mL, 9.36 mmol) to 4-(4-{3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-ureido}-isoquinolin-1-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (1.4 g, 2.34 mmol) in dichloromethane (20 mL) at room temperature and stir overnight. Evaporate the solvent under reduced pressure to give the title compound (1.3 g) as a white solid (quantitative). ES+ (m/z): 497.4 (M+H).

Workup

  1. customEvaporate the solvent under reduced pressure

Sources & evidence

ORD record
ord-a43a492030de4643935924516bc2c23c
Source dataset
uspto-grants-2009_09
Patent number
US07582638B2

Reaction notes

Loading…