反应详情

Stir 4-(4-{3-[5-(2-fluoro-1-fluoromethyl-1-methyl-ethyl)-2-p-tolyl-2H-pyrazol-3-yl]-ureido}-isoquinolin-1-yloxy)-piperidine-1-carboxylic acid tert-butyl ester (1.1 mmol, 0.6 g) and dissolve in 5 mL of dichloromethane and hydrogen chloride 4.0 M in dioxane (5.3 mmol, 1.3 mL) at room temperature overnight. Concentrate under reduced pressure. Triturate the white solid formed with diethyl ether. LCMS ES+ (m/z) 535 [M+H].

1. customat room temperature
2. customovernight
3. concentrationConcentrate under reduced pressure
4. customTriturate the white solid
5. customformed with diethyl ether