Methanesulfonic Acid → 1-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea mesylate

Participants

Reaction Steps

Dissolve 0.3 g of 1-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy] isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea in dichloromethane 1 mL and add 321 μL of a solution of methanesulfonic acid 1 N in dichloromethane. Evaporation of solvent under reduced pressure gives 0.357 g of the title compound as a white solid (quantitative). ES+ (m/z) 579.3 (M+H).

Provenance & Evidence