Methanesulfonic Acid → 1-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea mesylate

HRID 729626Notes

Reaction equation

HRID 729626 reaction equation
[CH3:1][C:2]1([C:5]([N:7]2[CH2:12][CH2:11][CH:10]([O:13][C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([NH:24][C:25]([NH:27][C:28]4[N:29]([C:37]5[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=5)[N:30]=[C:31]([C:33]5([CH3:36])[CH2:35][CH2:34]5)[CH:32]=4)=[O:26])=[CH:16][N:15]=3)[CH2:9][CH2:8]2)=[O:6])[CH2:4][CH2:3]1.[CH3:44][S:45]([OH:48])(=[O:47])=[O:46]>ClCCl>[S:45]([OH:48])(=[O:47])(=[O:46])[CH3:44].[CH3:1][C:2]1([C:5]([N:7]2[CH2:8][CH2:9][CH:10]([O:13][C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[C:17]([NH:24][C:25]([NH:27][C:28]4[N:29]([C:37]5[CH:42]=[CH:41][C:40]([CH3:43])=[CH:39][CH:38]=5)[N:30]=[C:31]([C:33]5([CH3:36])[CH2:35][CH2:34]5)[CH:32]=4)=[O:26])=[CH:16][N:15]=3)[CH2:11][CH2:12]2)=[O:6])[CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 160614691-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy] isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea

Product 1

HCID 866244461-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy]-isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea mesylate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Dissolve 0.3 g of 1-{1-[1-(1-Methyl-cyclopropanecarbonyl)-piperidin-4-yloxy] isoquinolin-4-yl}-3-[5-(1-methyl-cyclopropyl)-2-p-tolyl-2H-pyrazol-3-yl]-urea in dichloromethane 1 mL and add 321 μL of a solution of methanesulfonic acid 1 N in dichloromethane. Evaporation of solvent under reduced pressure gives 0.357 g of the title compound as a white solid (quantitative). ES+ (m/z) 579.3 (M+H).

Workup

  1. customEvaporation of solvent under reduced pressure

Sources & evidence

ORD record
ord-e7bbacc1f2094e1f9dc3e1d996d03727
Source dataset
uspto-grants-2009_09
Patent number
US07582638B2

Reaction notes

Loading…