1-Methyl-4-piperidone → HCID 1476965, compound

HRID 729639Notes

Reaction equation

HRID 729639 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH:14]=[C:4]1[C:5](=[O:8])[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3]1)[CH3:13]

Participants

4

Reactant 2

HCID 740491-Methyl-4-piperidoneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 1476965HCID 1476965, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 1-methylpiperidin-4-one (10 g, 88 mmol) in toluene (100 mL) was added 1,1-dimethoxy-N,N-dimethylmethanamine (52.7 g, 0.442 mol). The solution was heated to reflux overnight. The solvents were evaporated in vacuo, heptane (100 ml) was added and the solvents evaporated again to give the desired product. NMR indicated that the product was 70-80% pure and it was used in the next step without further purification.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux overnight
  3. customThe solvents were evaporated in vacuo, heptane (100 ml)
  4. additionwas added
  5. customthe solvents evaporated again

Sources & evidence

ORD record
ord-1878070c0c26483a8a9bc4ce5011bea2
Source dataset
uspto-grants-2009_09
Patent number
US07582643B2

Reaction notes

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