1-(Bromomethyl)-3-chloro-2-fluorobenzene → 2-[(3-Chloro-2-fluorobenzyl)thio]-4,6-pyrimidinediol

HRID 729659Notes

Reaction equation

HRID 729659 reaction equation
[SH:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([OH:9])[N:3]=1.[Cl:10][C:11]1[C:12]([F:19])=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH2:14]Br>>[Cl:10][C:11]1[C:12]([F:19])=[C:13]([CH:16]=[CH:17][CH:18]=1)[CH2:14][S:1][C:2]1[N:7]=[C:6]([OH:8])[CH:5]=[C:4]([OH:9])[N:3]=1

Participants

3

Reactant 2

HCID 5228271-(Bromomethyl)-3-chloro-2-fluorobenzeneHCID 178516656HCID 178516656, compound

Product 1

HCID 1785166532-[(3-Chloro-2-fluorobenzyl)thio]-4,6-pyrimidinediol

Procedure

The subtitle compound was prepared by the method of Example 19 step i) using 2-mercaptopyrimidine-4,6-diol (20.0 g) and 3-chloro-2-fluorobenzyl bromide to afford the subtitle compound as a white solid. Yield: 36.2 g.

Workup

  1. customThe subtitle compound was prepared by the method of Example 19 step i)

Sources & evidence

ORD record
ord-69cb2091ecd14235b8134ff3d876cfdc
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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