反应详情

Morpholine (5 ml) and sulfamide (11 g) in 1,4-dioxane (100 ml) were heated at reflux for 48 h. The solvent was evaporated under reduced pressure and the resulting solid partitioned between EtOAc and water. The organic phase was collected and the aqueous phase was further extracted with EtOAc (×4). The combined organic extracts were dried (MgSO4) and the solvent removed in vacuo. The solid residue was triturated with Et2O and filtered to give the subtitle compound as a white crystaline solid. Yield: 2.1 g.

1. temperatureat reflux for 48 h
2. customThe solvent was evaporated under reduced pressure
3. customthe resulting solid partitioned between EtOAc and water
4. customThe organic phase was collected
5. extractionthe aqueous phase was further extracted with EtOAc (×4)
6. dry with materialThe combined organic extracts were dried (MgSO4)
7. customthe solvent removed in vacuo
8. customThe solid residue was triturated with Et2O
9. filtrationfiltered