(R)-(-)-2-Amino-1-propanol → HCID 66701955, compound

HRID 729675Notes

Reaction equation

HRID 729675 reaction equation
Cl[C:2]1[N:7]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[N:5]=[C:4]([N:16]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:33])([CH3:32])[CH3:31])[S:17]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)(=[O:19])=[O:18])[CH:3]=1.[NH2:34][C@@H:35]([CH2:37][OH:38])[CH3:36]>CN1C(=O)CCC1>[CH2:9]([S:8][C:6]1[N:5]=[C:4]([N:16]([CH2:26][O:27][CH2:28][CH2:29][Si:30]([CH3:33])([CH3:32])[CH3:31])[S:17]([N:20]2[CH2:25][CH2:24][O:23][CH2:22][CH2:21]2)(=[O:19])=[O:18])[CH:3]=[C:2]([NH:34][C@H:35]([CH3:36])[CH2:37][OH:38])[N:7]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 86602822HCID 86602822, compound

Product 1

HCID 66701955HCID 66701955, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The subtitle compound was prepared as a yellow oil by the method of Example 43 step ii) by reacting the subtitle product of step i) (11.75 g) with (R)-alaninol (3.4 ml) in NMP (30 ml). Yield: 12.2 g.

Sources & evidence

ORD record
ord-81119f5743db485dbffd18226f130b48
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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