(R)-(-)-2-Amino-1-propanol → HCID 66701897, compound

HRID 729678Notes

Reaction equation

HRID 729678 reaction equation
[CH2:1]([S:8][C:9]1[N:14]=[C:13]([N:15]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[S:16]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)(=[O:18])=[O:17])[CH:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:33][C@@H:34]([CH2:36][OH:37])[CH3:35]>CN1C(=O)CCC1>[CH2:1]([S:8][C:9]1[N:14]=[C:13]([N:15]([CH2:24][O:25][CH2:26][CH2:27][Si:28]([CH3:31])([CH3:30])[CH3:29])[S:16]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)(=[O:18])=[O:17])[CH:12]=[C:11]([NH:33][C@H:34]([CH3:35])[CH2:36][OH:37])[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 80308(R)-(-)-2-Amino-1-propanolHCID 86602823HCID 86602823, compound

Product 1

HCID 66701897HCID 66701897, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The subtitle compound was prepared as a yellow oil by the method of Example 43 step ii) by reacting the subtitle product of step ii) (8.26 g) with (R)-alaninol (3.61 g) in NMP (60 ml). Yield: 7.6 g.

Sources & evidence

ORD record
ord-2e97a0ee75b4496283dde0080aa5c256
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

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