Sodium hydride → HCID 86602824, compound

HRID 729686Notes

Reaction equation

HRID 729686 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:12]=2[F:19])[N:3]=1.[CH3:20][S:21]([NH2:24])(=[O:23])=[O:22].[H-].[Na+].[CH3:27][Si:28]([CH3:35])([CH3:34])[CH2:29][CH2:30][O:31][CH2:32]Cl>>[Cl:8][C:6]1[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[C:12]=2[F:19])[N:3]=[C:2]([N:24]([CH2:32][O:31][CH2:30][CH2:29][Si:28]([CH3:35])([CH3:34])[CH3:27])[S:21]([CH3:20])(=[O:23])=[O:22])[CH:7]=1

Participants

5

Reactant 4

HCID 24758Sodium hydrideHCID 72879MethanesulfonamideHCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 85927872HCID 85927872, compound

Product 1

HCID 86602824HCID 86602824, compound

Procedure

The subtitle compound was prepared as a colourless oil by the method of Example 39 step iii) using the subtitle product of step v) (2.0 g), methanesulfonamide (0.60 g), 60% sodium hydride (0.50 g) and 2-(trimethylsilyl)ethoxymethyl chloride (1.11 ml). Yield: 2.42 g.

Sources & evidence

ORD record
ord-96689786a597469d86ec1bf6d4b5845f
Source dataset
uspto-grants-2009_09
Patent number
US07582644B2

Reaction notes

Loading…