4-Aminophenol → HCID 57833439, compound

HRID 729891Notes

Reaction equation

HRID 729891 reaction equation
NC1C=C(C=CC=1)OC1C=CN=C(C(N)=O)C=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=1.[Si:26]([O:33][CH2:34][CH2:35][NH:36][C:37]([C:39]1[C:44](Cl)=[CH:43][CH:42]=[CH:41][N:40]=1)=[O:38])([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:28])[CH3:27]>>[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:43]2[CH:42]=[CH:41][N:40]=[C:39]([C:37]([NH:36][CH2:35][CH2:34][O:33][Si:26]([C:29]([CH3:32])([CH3:31])[CH3:30])([CH3:27])[CH3:28])=[O:38])[CH:44]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 4034-AminophenolHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide2×HCID 67105837HCID 67105837, compound

Product 1

HCID 57833439HCID 57833439, compound

Procedure

4-(4-Aminophenoxy)-N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridine-2-carboxamide was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (Intermediate 2C), starting from 4-aminophenol and N-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)chloropyridine-2-carboxamide MS ES: 388 (M+H)+, calcd 388, RT=3.60 min.

Sources & evidence

ORD record
ord-f0542f5646fd4f64a6785f5c2440485b
Source dataset
uspto-grants-2009_09
Patent number
US07582645B2

Reaction notes

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