4-Aminophenol → 4-(2-Methyl-4-pyridinyloxy)aniline

HRID 729934Notes

Reaction equation

HRID 729934 reaction equation
N[C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[O:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12](N)=O)[CH:7]=1.[NH2:18]C1C=CC(O)=CC=1.ClC1C=CN=C(C)C=1>>[CH3:12][C:8]1[CH:7]=[C:6]([O:5][C:4]2[CH:3]=[CH:2][C:17]([NH2:18])=[CH:16][CH:15]=2)[CH:11]=[CH:10][N:9]=1

Participants

4

Reactant 3

HCID 4034-AminophenolHCID 5813924-Chloro-2-methylpyridineHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 230230754-(2-Methyl-4-pyridinyloxy)aniline

Procedure

{4-[(2-Methylpyridin-4-yl) oxy]phenyl} amine (2B) was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-aminophenol and 4-chloro-2-methylpyridine, MS ES: 201 (M+H)+, calcd 201, RT=1.01 min.

Sources & evidence

ORD record
ord-abbfd57b5ef04d6085fd0e3901ca3004
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Reaction notes

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