4-Aminophenol → HCID 53399142, compound

HRID 729938Notes

Reaction equation

HRID 729938 reaction equation
N[C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][CH:17]=1)[O:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]([NH2:14])=O)[CH:7]=1.[NH2:18]C1C=CC(O)=CC=1.ClC1C=CN=C(C#N)C=1>>[NH2:18][C:17]1[CH:16]=[CH:15][C:4]([O:5][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([C:12]#[N:14])[CH:7]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 4034-AminophenolHCID 6933424-Chloro-2-pyridinecarbonitrileHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 53399142HCID 53399142, compound

Procedure

4-(4-Aminophenoxy) pyridine-2-carbonitrile (21) was prepared by a method analogous to that described for 4-(3-aminophenoxy) pyridine-2-carboxamide (2C), starting from 4-aminophenol and 4-chloro-2-cyanopyridine, MS ES: 212 (M+H)+, calcd 212, RT=1.23 min.

Sources & evidence

ORD record
ord-3e42f08ce9494c60aa77fd60898bba3b
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Reaction notes

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