4-Chloro-2-pyridinecarbonitrile → 4-[4-Amino-3-(trifluoromethyl)phenoxy]pyridine-2-carbonitrile

HRID 729940Notes

Reaction equation

HRID 729940 reaction equation
NC1C=C(C=CC=1)O[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([C:12]([NH2:14])=O)[CH:7]=1.[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=1[C:26]([F:29])([F:28])[F:27].ClC1C=CN=C(C#N)C=1>>[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:6]2[CH:11]=[CH:10][N:9]=[C:8]([C:12]#[N:14])[CH:7]=2)=[CH:21][C:20]=1[C:26]([F:27])([F:28])[F:29]

Participants

4

Reactant 3

HCID 6933424-Chloro-2-pyridinecarbonitrileHCID 146928342-Amino-5-hydroxybenzotrifluorideHCID 231372294-(3-Aminophenoxy)pyridine-2-carboxamide

Product 1

HCID 578334414-[4-Amino-3-(trifluoromethyl)phenoxy]pyridine-2-carbonitrile

Procedure

This material is prepared by a method analogous to that described for preparation of 2C, starting from 4-amino-3-(trifluoromethyl) phenol and 4-chloro-2-cyanopyridine.

Workup

  1. customThis material is prepared by a method analogous to

Sources & evidence

ORD record
ord-b58e1343a7304e60af40ad249e5e5f1e
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Reaction notes

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