Boron tribromide → HCID 136183340, compound

HRID 729955Notes

Reaction equation

HRID 729955 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:14]=[C:13]([NH2:15])[N:12]=[C:11]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=4)=[CH:19][CH:18]=3)[CH:10]=2)=[CH:5][CH:4]=1.B(Br)(Br)Br>C(Cl)Cl>[NH2:15][C:13]1[N:14]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[CH:10]=[C:11]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([O:23][C:24]3[CH:29]=[CH:28][N:27]=[C:26]([CH3:30])[CH:25]=3)=[CH:21][CH:22]=2)[N:12]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 57833557HCID 57833557, compound

Product 1

HCID 136183340HCID 136183340, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The intermediate from Step 1 above is treated with BBr3 in methylene chloride at 0° C. for 12 h. After work-up and purification by a published procedure (J. F. W. McOmie and D. E. West, Org. Synth., Collect. Vol. V, 412 (1973)), the desired compound is obtained.

Workup

  1. customAfter work-up and purification
  2. customby a published procedure (J. F. W. McOmie and D. E. West, Org. Synth., Collect. Vol. V, 412 (1973))

Sources & evidence

ORD record
ord-0eb53e3866104f44bb790901c80d4509
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Reaction notes

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