1-Methylpiperazine → HCID 57833305, compound

HRID 729962Notes

Reaction equation

HRID 729962 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:24]=[CH:23][C:12]([O:13][C:14]3[CH:19]=[CH:18][N:17]=[C:16]([C:20]([OH:22])=O)[CH:15]=3)=[CH:11][CH:10]=2)[CH:5]=[C:4]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[N:3]=1.[CH3:31][N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1>>[CH3:31][N:32]1[CH2:37][CH2:36][N:35]([C:20]([C:16]2[CH:15]=[C:14]([O:13][C:12]3[CH:11]=[CH:10][C:9]([NH:8][C:6]4[CH:5]=[C:4]([C:25]5[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=5)[N:3]=[C:2]([NH2:1])[N:7]=4)=[CH:24][CH:23]=3)[CH:19]=[CH:18][N:17]=2)=[O:22])[CH2:34][CH2:33]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 57833428HCID 57833428, compound

Product 1

HCID 57833305HCID 57833305, compound

Procedure

This material is prepared by a method analogous to that described for Example 21, starting from 4-{4-[(2-amino-6-phenylpyrimidin-4-yl)amino]phenoxy} pyridine-2-carboxylic acid (Example 20) and 1-methylpiperizine. 1H NMR (DMSO-d6) δ 10.85 (s, 1H), 10.19 (s, 1H), 8.42 (d, 1H), 7.90 (m, 2H), 7.74 (m, 3H), 7.59 (m, 4H), 7.22 (m, 3H), 7.06 (m, 2H), 6.60 (s, 1H), 4.51 (m, 1H), 4.08 (m, 1H), 3.45 (m, 3H), 3.17 (m, 3H), 2.78 (s, 3H); MS ES 482 (M+H)+, calcd 482, RT=1.86 min.

Workup

  1. customThis material is prepared by a method analogous to

Sources & evidence

ORD record
ord-6a8ca136830b445a9988297b22451607
Source dataset
uspto-grants-2009_09
Patent number
US07582646B2

Reaction notes

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