HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylacetamide → 2-tert-Butyl-4-(4-fluorophenyl)oxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylacetamide | HCID 12957 | — |
| Reactant | 2-Bromo-1-(4-fluorophenyl)ethan-1-one | HCID 96749 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-tert-Butyl-4-(4-fluorophenyl)oxazole | HCID 66869043 | 1,254.2% |
Reaction Steps
Reflux a solution of commercially available 2-bromo-4′-fluoroacetophenone (100.00 g, 460 mmol), 2,2-dimethyl-propionamide (93.06 g, 20 mmol) in 1,4-dioxane (600 mL) for 2 days. Filter precipitate, concentrate filtrate, and purify (silica gel chromatography, eluting with hexanes:EtOAc 60:1) to give the title compound (55 g, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07582652B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-52788692ddab4fcba992ec967028d476 |
| Source note | uspto-grants-2009_09 |