反应详情

tert-Butyl 1-[(2S)-2-((3S)-3-{[(6-chloro-2-naphthyl)sulfonyl]amino}-2-oxopyrrolidin-1-yl)propanoyl]piperidin-3-ylcarbamate (0.6 g) was dissolved in DCM (11 ml) and trifluoroacetic acid (11 ml) was added. The mixture was stirred at room temperature for 2 h and then concentrated under reduced pressure. The residue was dissolved in water (5 ml) and ammonia solution (0.88%; 1 ml) added. The resultant aqueous mixture was extracted with DCM. The combined organic extracts were dried (over magnesium sulphate), filtered and concentrated under reduced pressure to give the title compound (0.38 g) as a white foam.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (5 ml)
3. additionammonia solution (0.88%; 1 ml) added
4. extractionThe resultant aqueous mixture was extracted with DCM
5. dry with materialThe combined organic extracts were dried (over magnesium sulphate)
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure