Methanesulfonic Acid → HCID 86626990, compound

HRID 730016Notes

Reaction equation

HRID 730016 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[NH:13][C:12]([C:14]2[N:19]=[C:18]3[N:20]([CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:21]([NH2:23])=[N:22][C:17]3=[CH:16][CH:15]=2)=[C:11]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:10]=1.[CH3:35][S:36]([OH:39])(=[O:38])=[O:37]>CO.O>[CH3:35][S:36]([OH:39])(=[O:38])=[O:37].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[NH:13][C:12]([C:14]2[N:19]=[C:18]3[N:20]([CH2:24][C:25]([CH3:26])([CH3:27])[CH3:28])[C:21]([NH2:23])=[N:22][C:17]3=[CH:16][CH:15]=2)=[C:11]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[N:10]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 11705579HCID 11705579, compound

Product 1

HCID 86626990HCID 86626990, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Treat a solution of 5-[2-(2-Chloro-6-fluoro-phenyl)-5-phenyl-3H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-ylamine in methanol-water with methanesulfonic acid followed by lyophilization to provide the title compound.

Sources & evidence

ORD record
ord-1fc914c486294a2db82e16a4adb53d3a
Source dataset
uspto-grants-2009_09
Patent number
US07582652B2

Reaction notes

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