Methanesulfonic Acid → HCID 86626991, compound

HRID 730017Notes

Reaction equation

HRID 730017 reaction equation
[C:1]([C:5]1[NH:9][C:8]([C:10]2[N:15]=[C:14]3[N:16]([C@H:20]([CH3:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:17]([NH2:19])=[N:18][C:13]3=[CH:12][CH:11]=2)=[C:7]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:33][S:34]([OH:37])(=[O:36])=[O:35]>CO.O>[CH3:33][S:34]([OH:37])(=[O:36])=[O:35].[C:1]([C:5]1[NH:9][C:8]([C:10]2[N:15]=[C:14]3[N:16]([C@H:20]([CH3:25])[C:21]([CH3:24])([CH3:22])[CH3:23])[C:17]([NH2:19])=[N:18][C:13]3=[CH:12][CH:11]=2)=[C:7]([C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)[N:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 68867495HCID 68867495, compound

Product 1

HCID 86626991HCID 86626991, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Treat a solution of 5-[2-tert-butyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-3-(1(R),2,2-trimethyl-propyl)-3H-imidazo[4,5-b]pyridin-2-ylamine in methanol-water with methanesulfonic acid followed by lyophilization to provide the title compound.

Sources & evidence

ORD record
ord-b8181418c52e45d4bedd85bafa52b3b6
Source dataset
uspto-grants-2009_09
Patent number
US07582652B2

Reaction notes

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