Methanesulfonic Acid → HCID 86626992, compound

HRID 730019Notes

Reaction equation

HRID 730019 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[NH:13][C:12]([C:14]2[N:19]=[C:18]3[N:20]([C@H:24]([CH3:29])[C:25]([CH3:28])([CH3:27])[CH3:26])[C:21]([NH2:23])=[N:22][C:17]3=[CH:16][CH:15]=2)=[C:11]([C:30]2[CH:35]=[CH:34][C:33]([F:36])=[CH:32][CH:31]=2)[N:10]=1.[CH3:37][S:38]([OH:41])(=[O:40])=[O:39]>CO.O>[CH3:37][S:38]([OH:41])(=[O:40])=[O:39].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[NH:13][C:12]([C:14]2[N:19]=[C:18]3[N:20]([C@H:24]([CH3:29])[C:25]([CH3:28])([CH3:27])[CH3:26])[C:21]([NH2:23])=[N:22][C:17]3=[CH:16][CH:15]=2)=[C:11]([C:30]2[CH:31]=[CH:32][C:33]([F:36])=[CH:34][CH:35]=2)[N:10]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 68870531HCID 68870531, compound

Product 1

HCID 86626992HCID 86626992, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

Treat a solution of 5-[2-(2,6-difluoro-phenyl)-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-3-(1(R),2,2-trimethyl-propyl)-3H-imidazo[4,5-b]pyridin-2-ylamine in methanol-water with methanesulfonic acid followed by lyophilization to provide the title compound.

Sources & evidence

ORD record
ord-95bcbbfb09964db9b3545351e8c9d26e
Source dataset
uspto-grants-2009_09
Patent number
US07582652B2

Reaction notes

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