反应详情

Add methanol (1,200 mL) to combined lots of 3-(2,2-dimethyl-propyl)-5-(4-fluoro-phenylethynyl)-3H-imidazo[4,5-b]pyridin-2-ylamine (37.30 g) and heat to reflux. Add activated charcoal (3.73 g, 10 wt %) and reflux for 1 h. Filter while slurry is hot, then add water (375 mL) to the filtrate with stirring at room temperature. Filter off solids, wash 2×100 mL water and dry under reduced pressure at 45-50° C. to provide 30.0 g (80%) of the desired compound.

1. temperatureheat to reflux
2. temperaturereflux for 1 h
3. filtrationFilter while slurry
4. filtrationFilter off solids
5. washwash 2×100 mL water
6. customdry under reduced pressure at 45-50° C.