1-(2-Fluoropyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione-1-oxime → HCID 136335781, compound

HRID 730046Notes

Reaction equation

HRID 730046 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8](=[N:18][OH:19])[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[O:10])[CH:5]=[CH:4][N:3]=1>Cl>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9](=[O:10])[C:8]([C:6]2[CH:5]=[CH:4][N:3]=[C:2]([O:10][CH:9]([CH3:11])[CH3:8])[CH:7]=2)=[N:18][OH:19])=[CH:12][CH:13]=1

Participants

3

Reactant 1

HCID 1363357801-(2-Fluoropyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione-1-oxime

Product 1

HCID 136335781HCID 136335781, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 22b (200 mg; 0.76 mmol) in HCl-saturated isopropanol (15 ml) was stirred under reflux for 2.5 h. The solution was concentrated and the yellowish-white residue was triturated with a little ethanol, filtered off and dried.

Workup

  1. temperatureunder reflux for 2.5 h
  2. concentrationThe solution was concentrated
  3. customthe yellowish-white residue was triturated with a little ethanol
  4. filtrationfiltered off
  5. customdried

Sources & evidence

ORD record
ord-03f6e56db9ef4a2e934d1d9ecb9141b4
Source dataset
uspto-grants-2009_09
Patent number
US07582660B2

Reaction notes

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