Aniline → HCID 178503386, compound

HRID 730056Notes

Reaction equation

HRID 730056 reaction equation
F[C:2]1[CH:7]=[C:6]([C:8]2[NH:9][C:10]([S:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[NH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[F:19][C:16]1[CH:17]=[CH:18][C:13]([C:12]2[N:11]=[C:10]([S:20][CH3:21])[NH:9][C:8]=2[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([NH:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:7]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 178503385HCID 178503385, compound

Product 1

HCID 178503386HCID 178503386, compound

Procedure

Using the general method C, the title compound was prepared from 25b (0.2 g; 0.7 mmol) and aniline (0.65 g; 7.0 mmol) after a reaction time of 6 hours under reflux and separation by column chromatography (SiO2 60, CH2Cl2/EtOH 9+1). M.p. 228° C.

Workup

  1. temperatureunder reflux
  2. customseparation by column chromatography (SiO2 60, CH2Cl2/EtOH 9+1)

Sources & evidence

ORD record
ord-5d1c9f2c839c4f6d8bcacb0790b12a7e
Source dataset
uspto-grants-2009_09
Patent number
US07582660B2

Reaction notes

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